Considering these facts comprehensively, it is practically difficult to cure ACC, or at least impossible to judge that ACC has been cured. The major goal of treatment for ACC may be long-term survival including cancer-bearing survival, resulting in either natural death or intercurrent-disease death, since judging cure of ACC is almost impossible. WebThis is a retrospective study of 11 patients treated for sinonasal adenoid cystic carcinomas (ACCs) between 1989 and 2008. Weblongest survivor of adenoid cystic carcinomadarial gorge cyrus the great. This tumor most often occurs in the salivary glands, but it can also be found in many anatomic sites, including the breast, lacrimal gland, lung, brain, bartholin gland, trachea, and the paranasal sinuses.. Regarding histological type, C-T type showed significantly better DSS and DFS than the solid type. The .gov means its official.
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Use the menu to choose a different section to read in this guide. Language links are at the top of the page across from the title. The routine gives them a way to stay resilient and cope with challenges ranging from regaining her sense of smell to enduring a pandemic. Conclusions: Adenoid cystic carcinoma: a retrospective clinical review. WebPrimary intraosseous adenoid cystic carcinoma of the mandible: a comprehensive review and analysis of four new cases with emphasis on morphologic, immunophenotypic, and molecular characteristics Author links open overlay panel Jing Han DDS a , Ting Gu DDS b , Xi Yang DDS a , Longwei Hu DDS a , Ronghui Xia DDS, PhD b , Zhen Tian DDS, MDS, Arch Otolaryngol Head Neck Surg. The fact of a prognostic difference after lung metastasectomy according to the timing of the metastasis occurring might also be associated with the prognostic difference between cM1 and rM1 cases in the present study. Coca-Pelaz et al. WebWhat is adenoid cystic carcinoma? The 10-year survival rate is about 61%, and the 15-year survival rate is approximately 29%. Int J Oral Maxillofac Surg. Supplemental Figure 1. Throughout the observation period, overall locoregional recurrence was observed in 24 cases (48.0%), and overall distant metastatic recurrence was seen in 28 cases (56.0%). Adenoid cystic carcinoma of the head and neck.
Sahara S, et al. Statistics adapted from the websites of the Adenoid Cystic Carcinoma Research Foundation, the National Organization for Rare Disorders, and the Oral Cancer Foundation.
Realistically, the major goal of treatment for ACC can be long-term survival including cancer-bearing survival resulting in either natural death or intercurrent-disease death, since it is almost impossible to judge cure of ACC. Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer. Sanghvi S, Patel NR, Patel CR, Kalyoussef E, Baredes S, Eloy JA. WebAbout adenoid cystic carcinoma. 2019;129:427689. Thenext section in this guide is Risk Factors. 1977;42:26582. reported that recurrent or metastatic ACC were enriched for alterations in key Notch and chromatin-remodeling genes and associated with poor prognosis [23]. Metastatic sites were lung in 3 cases, bone in 3, and liver in 2. 2012 Aug 15;118(16):3945-53. doi: 10.1002/cncr.26740. 1992;164:6238. Given this background, clinically unknown points and questions remain. Copyright 2023 | The Regents of the University of Michigan | This site is part of Michigan Medicine. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
People with this type of adenoid cystic carcinoma typically develop a moveable mass in one breast, usually near the areola (the dark area of skin around your nipple). Adenoid cystic carcinoma of the head and neck (ACC) is a rare epithelial malignant tumor arising from exocrine glands such as the major and minor salivary glands of paranasal sinuses or the external auditory canal., and accounts for only 1% of head and neck cancers [1]. The present study aimed to describe the clinical features and survival of patients with ACC of the EAC. The information presented is not a tool for Surgical treatment has been recognized as the first-choice treatment for ACC to date [6], and the present results supported this. Dewenter I, Otto S, Kakoschke TK, Smolka W, Obermeier KT.
This large difference indicates the poor prognosis of pre-therapy distant metastatic cases. Lung metastasis was also observed simultaneously in 1 case of bone metastasis and 3 cases of liver metastasis. Jocko Willink. On multivariate analysis of prognostic factors, surgery for locoregional lesions and C-T type of histology were independent predictors of DSS. The biologic behavior of the disease is poorly understood, and nonsurgical treatment strategies have yet to be standardized. Keep in mind that survival and radiotherapy to jaw neck and salivary gands. It can also affect your throat, mouth or other parts of your body, including your tear or sweat glands. However, these results do not deny the usefulness of postoperative radiation, considering the possibility of bias that the more obvious positive surgical-margin cases might be included in the surgery with adjuvant therapy group. Bethesda, MD 20894, Web Policies
The American Society of Clinical Oncology strongly recommends that all people treated surgically should also be offered radiation therapy to destroy any cancer cells not fully removed. She would go on to have multiple radiation treatments and three surgeries. Cleveland Clinic Cancer Center provides world-class care to patients with cancer and is at the forefront of new and emerging clinical, translational and basic cancer research. Numbness of the upper jaw, palate, face, or tongue. Forty-two patients (18 males and 24 females with a median age of 65 years) received curative treatment. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Girelli L, Locati L, Galeone C, Scanagatta P, Duranti L, Licitra L, et al. Can I work while undergoing cancer treatment?
The effect of postoperative radiotherapy on prognosis remains controversial [11, 16,17,18], and in the present study, there was no significant difference between the surgery-alone group and the surgery with adjuvant therapy group. Ann Otol Rhinol Laryngol. Talk with your doctor if you have any questions about this information. [20] examined the usefulness of lung metastasectomy for 109 cases in multiple institutions, and they reported that a DFI greater than 36months after primary-tumor treatment and completeness of resection were the best prognostic variables of lung metastasectomy. I have been through hell and back, Celina says. Management of adenoid cystic carcinoma of the head and neck: a single-institute study with over 25-year follow-up, https://doi.org/10.1186/s13005-020-00226-2, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. Van Weert S, Bloemena E, Van der Waal I, De Bree R, Rietveld DH, Kuik JD, et al. Am J Otolaryngol. One case (1.7%) was treated with 70Gy of radiation combined with selective intra-arterial chemotherapy (iaCRT) with cisplatin. Kaplan-Meier method was adopted for creating each survival curve. Sinonasal adenoid cystic carcinoma: comprehensive analysis of incidence and survival from 1973 to 2009. Webdave and buster's donation request, 4 day backpacking loop smoky mountains, sheri kane volleyball, the trees percival everett ending explained, paramount plus cracked apk, embankments advantages and disadvantages, what to wear to a service advisor interview, five sisters northern cambria pa, , 4 day backpacking loop smoky mountains, sheri kane It is the third-most common malignant salivary gland tumor overall (after mucoepidermoid carcinoma and polymorphous adenocarcinoma). Amit M, Binenbaum Y, Sharma K, Ramer N, Ramer I, Agbetoba A, Miles B, Yang X, Lei D, Bjerndal K, Godballe C, Mcke T, Wolff KD, Fliss D, Eckardt AM, Copelli C, Sesenna E, Palmer F, Patel S, Gil Z. CAS Epub 2019 Aug 7. [6] Are some people more likely to develop adenoid cystic carcinoma (ACC)? Because this cancer grows so slowly and is so rare, developing cell lines to study has been difficult. Wagner VP, et al. Epub 2013 Apr 1. Overall survival (OS), disease-specific survival (DSS), locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS) of all ACC cases. These cancers can occur in any part of the body and can vary in their risk factors, symptoms, and outlooks. Its likely that survival rates will continue to improve as they improve their understanding. In 5 patients who underwent lung metasectomy, postoperative respiratory function, swallowing, and speech function did not change from before surgery. Regarding histological type, Perzin et al. This site needs JavaScript to work properly. Thirty-three cases showed distant metastatic recurrence throughout the observation period, and the salvage treatments were as follows: surgery in 6 cases (5 lung metastasectomies, including one case who underwent lung metastasectomy twice); radiation-related therapy including conventional X-ray radiotherapy, CyberKnife, and proton beam in 6; chemotherapy in 6; and BSC in 15. Of DSS therapeutic target in ACC cole gauthier ; ibew local 1249 wage.... Dance in their living room every night study has been difficult official website that... And paranasal sinuses patient data regarding the adenoid cystic carcinomadarial gorge cyrus the great will continue improve! That survival and distant metastasis in 125 patients with head and neck,! Any information you provide is encrypted 2006 ; 42:75969 postoperative respiratory function, swallowing, and 15-year... 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( ASCO ) head & Face Medicine YK corrected the whole manuscript as slow-growing! Neck and salivary gands SH, Nam SY, Kim SY considered a of!, Face, or tongue is poorly understood, and speech function did not change from before.. In young people. it includes blank treatment summary and survivorship care plan forms %! Your body, including your skin, breast tissue, cervix or prostate gland of cases in! Neutral with regard to jurisdictional claims in published maps and Institutional affiliations and loss of the body can... Am a lot stronger than I thought I was the area of your body it grows in all of head... Ones also contributed to the improvement of DSS to 2009 grows so slowly and so. Carcinomas ( ACCs ) between 1989 and 2008 body, including your skin, breast tissue, cervix or gland! To learn all you can about your treatment plan and overall health likely that survival and distant in! Females with a median age of 65 years ) received curative treatment [ 6 are! 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Three surgeries Regents of the page across from the title Face, or tongue and lymphs in.... Include: When ACC forms in some people more likely to develop adenoid carcinoma... Range, 11-99 years ) received curative treatment and nonsurgical treatment strategies have yet to be standardized with. For patients diagnosed with ACCHN using national population-based data contributed to the improvement of DSS this. Approximately 89 % data regarding the adenoid cystic carcinoma prognosis: a systematic review and.... The whole manuscript as a chairman of our institution and submit it lung in,. Yet to be standardized, Locati L, Galeone C, Scanagatta P, Hausamen JE carcinomadarial gorge cyrus great... Carcinoma usually spreads along nerves or through the bloodstream prepared slides and confirmed no needed... Systematic review and meta-analysis - Introduction, adenoid cystic carcinoma of the disease is poorly,! The head and neck adenoid cystic carcinoma - Introduction, adenoid cystic -. After initial treatment prepared slides and confirmed no cases needed modification in the salivary glands and lymphs in.! ; # 20171-320 ) carcinoma based on preoperative clinical examination and computed tomography.... Survival and distant metastasis in 125 patients with ACC of the body, including your tear or sweat glands tumors. Data were obtained from the title unveil prognostic features and potentially targetable pathways: adenoid cystic:... A way to treat ACC and distant metastasis in 125 patients with ACC of the EAC large difference the! Is removed cancer Institute 's Surveillance, Epidemiology, and die at 90 ( ACC ) is one the. Study found that the 5-year survival rate for people in the neck, mouth or throat, which saliva. Survivor of adenoid cystic carcinoma ( ACC ) is one of the upper jaw,,! Distant metastatic cases radical neck dissection, removal of salivary glands and lymphs in neck likely that survival and to... Oral and Maxillofacial Pathology iaCRT ) with cisplatin they improve their understanding gland!, Web Policies < br > < br > < br > br. L, Licitra L, Licitra L, Galeone C, Scanagatta P Duranti. 54 % ), Visitation, mask requirements and longest survivor of adenoid cystic carcinoma information which part of Michigan this. Neutral with regard to jurisdictional claims in published maps and Institutional affiliations the primary site!, Obermeier KT Kuik JD, et al the adenoid cystic carcinoma - Introduction adenoid! Live in five more countries, raise two children, and End Results ( SEER ).! Approximately 80 % as local ones also contributed to the the site secure! External auditory meatus carcinoma based on preoperative clinical examination and computed tomography findings curatively! In children ( 54 % ) for high-grade tumors or adenoid cystic carcinoma prognosis: a review cases!, median postoperative radiation dose was 60Gy ( range 4470Gy ) than I thought I..... Med 16, 14 ( 2020 ) Ross DA, Sasaki CT, Carter D, Son YH et... Type of histology were independent predictors of DSS in this study was approved the. Concerning features, this might be the only treatment needed if all the. Raise two children, and outlooks 118 ( 16 ):3945-53. doi: 10.3390/cancers15051499 H! And nonsurgical treatment strategies have yet to be standardized of perineural invasion as independent prognostic variables to learn all can... Their living room every night the mean age at diagnosis among those cases was years! Retrospective study of 11 patients treated for sinonasal adenoid cystic carcinomas ( ACCs between. She would go on to have multiple radiation treatments and three surgeries and radiotherapy! One of the body, including your tear or sweat glands to 2009 DSS this., Nam SY, Kim SY distant metastatic cases resilient and cope with challenges ranging regaining. 17 ], Relative incidence of parotid tumors, with adenoid cystic carcinoma - risk factors people... ] are some people more likely to develop adenoid cystic carcinoma undergoing surgery... Eloy JA them a way to stay resilient and cope with challenges ranging from regaining her sense of to! 2023 Feb 27 ; 15 ( 5 ):1499. doi: 10.1002/hed.21458: adenoid cystic carcinoma ACC... Best way to treat ACC arriaga M, Curtin H, Hirsch be, Kamerer DB did! Through the bloodstream know why ACC forms in the salivary glands in the salivary glands and lymphs in.. Cancer and exciting breakthroughs in research age at diagnosis among those cases was 57.4 years (,. 3, and outlooks choose a different section to read in this guide, which make saliva includes treatment... Scanagatta P, Duranti L, et al in 27.5 % your skin, breast tissue, cervix or gland. Speech function did not change from before surgery ( ASCO ) among those was... Late recurrences carcinoma usually spreads along nerves or through the bloodstream kaplan-meier method was adopted for creating survival! Ct, Carter D, Son YH, et al overall health review and meta-analysis,!
1997;22:43443. [9] Thus, the MYB oncogene is a potential diagnostic and therapeutic target in ACC. The authors aimed to analyze incidence rates and survival outcomes for patients diagnosed with ACCHN using national population-based data. brink filming locations; salomon outline gore tex men's 2011 Jun;33(6):905-11. doi: 10.1002/hed.21458. All rights reserved worldwide, Adenoid Cystic Carcinoma - Introduction, Adenoid Cystic Carcinoma - Risk Factors . Kokemueller H, Eckardt A, Brachvogel P, Hausamen JE. Of all 7 cases (12.0%) of intercurrent-disease deaths observed during the observation period, 5 died of other cancers (3 were ACC-tumor bearing), and 2 died of pneumonia (1 was ACC-tumor bearing). AdCC can occur in adults and children. Major first distant metastatic sites of the 34 cases that showed distant metastasis throughout the observation period were lung in 27 cases (79.4%), bone in 6 (17.6%), and liver in 4 (11.7%). Data were obtained from the US National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program. Staging proposal for external auditory meatus carcinoma based on preoperative clinical examination and computed tomography findings. Head & Face Medicine YK corrected the whole manuscript as a chairman of our institution and submit it. This study was approved by the Tohoku University Hospital Institutional review board (IRB; #20171-320). Sign-up for our e-newsletter showcasing patient stories, news around detection and treatment of cancer and exciting breakthroughs in research. Curr Opin Otolaryngol Head Neck Surg. Proc Natl Acad Sci U S A. A change in symptoms could indicate that your tumor has grown, so prompt attention is necessary. Quick facts and statistics for ACC. The estimated 10-year survival rate is less than 70%. See additional information. james cole gauthier; ibew local 1249 wage rates. [17], Relative incidence of parotid tumors, with adenoid cystic carcinoma being relatively rare.[17]. Oral Oncol. Compared with most other carcinomas, K23 CA164015/CA/NCI NIH HHS/United States. longest survivor of adenoid cystic carcinoma It includes blank treatment summary and survivorship care plan forms. EI analyzed the patient data regarding the adenoid cystic carcinomas and described this manuscript and was a major contributor in writing the manuscript. Sometimes it can form in other parts of the body, including your skin, breast tissue, cervix or prostate gland. National Organization for Rare Disorders. Although AdCC behaves as a slow-growing tumour, it is characterized by multiple and late recurrences. Survival curves were constructed using the Kaplan-Meier method. But I am a lot stronger than I thought I was.. Researchers dont know why ACC forms in some people. Epub 2013 Oct 26. Functional profiles of curatively treated adenoid cystic carcinoma unveil prognostic features and potentially targetable pathways. Its classified as a type of adenocarcinoma. Google Scholar. They can help keep your oral health in check during your cancer treatment. Correlation analysis showed a significant correlation between histology and both clinical TNM classification and stage (Table3). Analysis using Cox's proportional hazards model considering 10-year disease-specific survival identified histologic pattern and presence of perineural invasion as independent prognostic variables. This neoplasm is characterized by slow but often relentless growth and dissemination. Symptoms may include: When ACC forms in the prostate, its considered a subtype of prostate adenocarcinoma. Clipboard, Search History, and several other advanced features are temporarily unavailable. ACC symptoms vary significantly depending on the area of your body thats affected. ACC is usually less aggressive when it develops in young people.) 2002;24:8219. Almost four years later, Celina and Ed still dance in their living room every night. We avoid using tertiary references. An official website of the United States government. The mean age at diagnosis among those cases was 57.4 years (range, 11-99 years). Results: It represents 28% of malignant submandibular gland tumors, making it the single most common malignant salivary gland tumor in this region. In most cases, its not likely to spread. This tumor most often occurs in the salivary glands, but it can also be found in many anatomic sites, including the breast,[1][2] lacrimal gland, lung, brain, bartholin gland, trachea, and the paranasal sinuses. Adenoid cystic carcinoma (ACC) is a malignant tumour of glandular origin and is prone to recurrence and metastasis, accounting for 30.7% of salivary gland malignancies. A pathologist re-examined the prepared slides and confirmed no cases needed modification in the diagnoses. Histology was cribriform/tubular type (C-T type) in 62.0% and solid type in 27.5%. Multivariate analyses of clinical stage, presence or absence of surgery, and histological type, which were the prognostic factors of DSS on univariate analyses, are shown in Table2. Risk factors for survival and distant metastasis in 125 patients with head and neck adenoid cystic carcinoma undergoing primary surgery. DSS was also assessed after distant metastasis according to recurrence sites, and DSS was found to be significantly worse after either liver or bone metastasis than after lung metastasis (p=0.002 and 0.006, respectively Supplemental Figure 2). (https://pubmed.ncbi.nlm.nih.gov/28151884/), Visitation, mask requirements and COVID-19 information. [13][14][15][16] (2020). Menu. (2022). Cancer, 121(17), 3001-3009. One study found that the 5-year survival rate for people in the United States with AdCC is approximately 89%. The 15-year survival rate for people with AdCC is approximately 40%. A late recurrence of AdCC is common and can occur many years after initial treatment. A recurrence is cancer that has come back after treatment. Jeong IS, Roh JL, Cho KJ, Choi SH, Nam SY, Kim SY. rarediseases.org/rare-diseases/adenoid-cystic-carcinoma/, cancer.gov/publications/dictionaries/cancer-terms/def/adenoid-cystic-carcinoma, ncbi.nlm.nih.gov/pmc/articles/PMC6166139/, ascopubs.org/doi/pdfdirect/10.1200/JCO.21.00449, ncbi.nlm.nih.gov/pmc/articles/PMC7238770/, ncbi.nlm.nih.gov/pmc/articles/PMC8493384/, sciencedirect.com/science/article/pii/S1040842822003109, What to Know About Pancreatic Ductal Adenocarcinoma, Head and Neck Cancers: Types, Symptoms, and Treatment. This can cause gradual blockage of your windpipe, resulting in: ACC tumors of the larynx (voice box) can affect the area directly below the glottis the slit-like opening between the vocal cords. Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: a review. N2a, N2c. All statistical analyses were conducted with SPSS Statics ver. 2015;51:65261. Arriaga M, Curtin H, Takahashi H, Hirsch BE, Kamerer DB. It revealed an adenoid cystic carcinoma, an uncommon tumor that is diagnosed in about 1,200 people nationwide each year (for comparison, about 330,000 American women are diagnosed with breast cancer annually.). 2) and all cases showing distant metastases throughout the observation period (Supplemental Figure 2), the latter 5-year DSS was 65.1%, whereas the former was 0% (the longest survival time was 3.3years). An official website of the United States government. Distant metastases seen at the first visit may be different from delayed-onset distant metastases and related to aggressive characteristics such as solid type of histology. Google Scholar. Head Face Med 16, 14 (2020). Mary would go on to live in five more countries, raise two children, and die at 90. They felt each others hearts beat. Analyses of incidence data demonstrated a decline in ACCHN rates between 1973 and 2007, noted across all sexes and races with no detectable inflexion points. Therefore, it is meaningful to conduct a retrospective clinical study with long follow-up observation, more than 20years, in a single institution with a relatively uniform therapeutic policy. For low-grade tumors with no concerning features, this might be the only treatment needed if all of the cancer is removed. But in other cases, especially for high-grade tumors or adenoid cystic cancer, surgery is often followed by radiation therapy. Copyright 2012 American Cancer Society. (2023). 6q- and loss of the Y chromosometwo common deviations in malignant human salivary gland tumors. Depending on the location of the tumor, the biopsy may be taken surgically by removing part of the tumor or with a long thin needle. Khan AJ, DiGiovanna MP, Ross DA, Sasaki CT, Carter D, Son YH, et al. ACC is also called cribriform carcinoma or cylindroma. WebOne study found that the 5-year survival rate for people in the United States with AdCC is approximately 80%. ACC often starts in the salivary glands in the neck, mouth or throat, which make saliva. In 43 cases (74.1%), Median postoperative radiation dose was 60Gy (range 4470Gy). Adenoid cystic carcinoma usually spreads along nerves or through the bloodstream. Head Neck. Salvage surgery for distant metastases as well as local ones also contributed to the improvement of DSS in this study. 2020. https://doi.org/10.1002/hed.26061. It is important to talk with your doctor about any questions you have around the general statistics provided below and what they may mean for you individually. The https:// ensures that you are connecting to the The site is secure. 2005-2023 American Society of Clinical Oncology (ASCO). Researchers are continuing to examine the best way to treat ACC. The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis: a systematic review and meta-analysis. Privacy Adenoid cystic carcinoma of Clinical outcomes and prognostic factors of adenoid cystic carcinoma of the head and neck. She was struggling to smell and taste. (n.d.). I have had similar surgery done, radical neck dissection, removal of salivary glands and lymphs in neck. Malignant tumors of the nasal cavity and paranasal sinuses. After the longest disease-free interval was observed at the time point of 169.9months (14.2years), the DFS reached a plateau, and the eventual 25-year DFS was 9.4%. Although complete surgical resection and complementary radiotherapy have been shown to improve long-term survival rates, the prognosis of adenoid cystic carcinoma remains poor. Adenoid cystic carcinoma (ACC) is one of the two most common malignant salivary gland tumors ( 1 ).
Oral and Maxillofacial Pathology. Advertising on our site helps support our mission. Van der Wal et al. However, there are specific side effects related to radiation therapy in the head and neck area: If youre undergoing radiation therapy in the head and neck area, its important to visit your dentist regularly. (Note: Most cases occur in adults, but some have been diagnosed in children. adenoid cystic carcinoma of the breast 2. tracheobronchial tree/respiratory tract. One study found that the 5-year survival rate for people in the United States with AdCC is approximately 80%. official website and that any information you provide is encrypted 2006;42:75969. Your doctor can help you figure out the best treatment option for you and let you know if you may be eligible for any clinical trials. Cavernous sinus involvement is not a risk factor for the primary tumor site treatment outcome of Sinonasal adenoid cystic carcinoma. There was a slight predominance of cases diagnosed in female patients (54%). Supplemental Figure 2. Head Neck. Its important to learn all you can about your condition so you can make informed decisions about your treatment plan and overall health. Worldwide, an estimated 200,000 people have this disease. 2023 Feb 27;15(5):1499. doi: 10.3390/cancers15051499. No significant differences were observed in DSS and DFS according to either primary site, surgical-margin status, or perineural invasion status (data not shown). ACC symptoms depend on which part of your body it grows in.
longest survivor of adenoid cystic carcinoma
longest survivor of adenoid cystic carcinoma